NantHealth® to Present New Research Findings at the San Antonio Breast Cancer Symposium
Topics to include DNA and RNA profiling and next-generation sequencing of tumors
The Symposium, which will be held at the
“About 1 in 8 U.S. women or about 12.4% will develop invasive breast
cancer over the course of her lifetime. Such staggering statistics make
breast cancer research and progress critical,” said Sandeep “Bobby”
Reddy MD, Chief Medical Officer,
Title: “Germline potentially pathogenic variants in breast cancer
intrinsic molecular subtypes are not associated with somatic TMB”
Contributors: Sandeep “Bobby” Reddy MD; Lori J. Goldstein, MD;
Description: Comprehensive DNA and RNA profiling of 270 patients revealed intrinsic molecular subtypes of breast cancer have significantly distinct profiles of pathogenic germline variants. However, despite some breast cancer subtypes having higher frequency of germline pathogenic variants within DNA-damage repair genes, there is little evidence that these patients have subsequently higher mutational burden within their somatic genomes.
Key Takeaway: Pathogenic germline variants in key DNA damage repair genes such as BRCA1/2 are likely not adequate biomarkers for immune checkpoint therapy response, but are potentially biomarkers of differential tumorigenesis pathways.
Title: “Time-course DNA and RNA profiling of tumors from
intra-patient cross-over trial of sequential use of aromatase inhibitors”
Description: Early analysis from the ongoing NEOLETEXE trial examines a time-series of biopsies taken while transitioning patients from steroidal to non-steroidal aromatase inhibitors (AI) and vice versa. Acquired markers of AI-therapy resistance, and potential markers of sequential therapy sensitization, were explored. Two months after initial therapy, mutational burden decreased and clonality increased, yet by 4mo post-initialization mutations particularly in PIK3CA had repopulated.
Key Takeaway: Switching AI therapies sequentially in a clinical study is a model system to study differences in anti-tumor-effects of AIs. This ongoing trial may lead to a novel strategy to resensitize tumors to hormonal treatment and to elucidate the differences between steroidal and non-steroidal AIs.
Title: “Identification of a neoantigen targeted by
tumor-infiltrating lymphocytes in a patient with Her2+ breast cancer”
Description: In our study, we identify tumor infiltrating T-cells (TILS) that recognize tumor specific mutations (Neoepitopes) found by next-generation sequencing of breast cancer tumors. These identified TILS are further immortalized and characterized to bind the patient’s specific HLA alleles.
Key Takeaway: Identification of TILS recognizing patient specific neoepitopes allow development of personalized medicine in a pre-clinical setting.
Since 1977, the San Antonio Breast Cancer Symposium mission has been to provide state-of-the-art information on breast cancer research. From a one-day regional conference, the Symposium has grown to a five-day program attended by a broad international audience of academic and private researchers and physicians from over 90 countries. For more information visit: https://www.sabcs.org/2018-SABCS-sup-sup.
NantOmics, a member of the